FIGURE

Fig. 1

ID

ZDB-FIG-110712-72

Publication

Gregory-Evans et al., 2011 - Gene-specific differential response to anti-apoptotic therapies in zebrafish models of ocular coloboma

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Fig. 1

Effect of drug treatment on wildtype zebrafish. A: Wildtype embryos were dosed continuously from 10 hpf with diferuloylmethane. Percentage survival of embryos at 6 dpf was determined for each treatment group (30 embryos/group), n=3, mean±SEM. Error bars smaller than the symbol are not visible. B-E: Left panels, wholemount eye; center panels, coronal retinal section; right panels, wholemount larvae. B: Wildtype phenotype untreated at 6 dpf. C: Wildtype phenotype at 6 dpf treated with 5 μM diferuloylmethane from 10 hpf. D: Wildtype phenotype at 6 dpf following 300 μM zVAD-fmk treatment. E: Wildtype phenotype at 6 dpf following 300 μM zFA-fmk treatment. Scale bar left panel=200 μm. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; RPE, retinal pigment epithelium, ON, optic nerve.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

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