FIGURE

Fig. 7

ID

ZDB-FIG-110322-49

Publication

Veth et al., 2011 - Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma

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Fig. 7

Analysis of retinal and optic nerve head pathology.

A The relative expression levels of genes previously associated with retinal neuron pathology measured by real-time PCR on cDNA made from RNA isolated from the eyes of 1-month TL and bugeye fish. The cell populations that predominantly express the marker genes are listed below the bar graph. n = 4 independent samples of 6 pooled eyes each from TL wild-type and bugeye mutant fish. Error bars show standard error of the mean; *p<0.05. B Histological cross sections through the optic nerve head in TL wild-type (left) and bugeye (right) samples a 6 months of age. C Representative electron micrographs showing each type of axon pathology observed in cross-sections of TL wild-type (top) and bugeye (bottom) optic nerves. Arrowheads (left), degenerating axon; arrows (middle), unraveling myelin sheath; asterisks (right), lost axon. Scale bar = 2 μm. D Quantification of the optic nerve ultrastructure analysis reported as number of axon pathologies per mm². n = 6 and 7 nerves for 7- and 12-month TL wild-type, respectively; n = 8 nerves each for 7- and 12-month bugeye.

Expression Data

Genes:	aif1l apoeb arg1 atf3 c1qc gap43 gfap jun klf6a socs3a socs3b thy1
Fish:	TL lrp2a^mw1/mw1
Anatomical Terms:	eye glial cell eye microglial cell eye retinal ganglion cell
Stage:	Days 30-44

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lrp2a^mw1/mw1
Observed In:	optic nerve head
Stage:	Adult

Phenotype Detail

Acknowledgments

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