FIGURE

Fig. 5

ID

ZDB-FIG-101118-31

Publication

Song et al., 2010 - Neural and Synaptic Defects in slytherin, a Zebrafish Model for Human Congenital Disorders of Glycosylation

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Fig. 5

A–C. mib excludes srn phenotypes. A. AAL staining is reduced in srn and srn + mib double mutants, but not in mib. B. srn + mib double mutants showed reduction of secondary motor neurons, more severe than srn but similar to mib alone. C. srn + mib double mutants have reduced GFAP+ glia, more severe than srn, but similar to mib alone (15 embryos, 2 carrier pairs for each). Scale bar = 40 μm. D–F. DAPT treatment excludes srn phenotypes. D. AAL staining is reduced in srn and srn mutants treated with DAPT, but not in DAPT treated embryos. E. srn mutants treated with DAPT showed reduction of secondary motor neurons, more severe than srn but similar to DAPT treated embryos. F. srn mutants treated with DAPT showed reduction of GFAP+ glia, more severe than srn, but similar to DAPT treated WT embryos (10 embryos, 2 carrier pairs for each). Scale bar = 40 μm.

Expression Data

Antibody:	zn-5
Fish:	gmds^{p31erb/p31erb} mib1^hi904Tg gmds^{p31erb/p31erb}; mib1^{hi904Tg/hi904Tg}
Anatomical Term:	secondary motor neuron
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gmds^{p31erb/p31erb}; mib1^{hi904Tg/hi904Tg}
Observed In:	secondary motor neuron spinal cord glial cell
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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