FIGURE

Fig. 7

ID

ZDB-FIG-101104-39

Publication

Liu et al., 2010 - A dual role for ErbB2 signaling in cardiac trabeculation

Other Figures

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Fig. 7

erbb2 mutants display progressive cardiac dysfunction. (A,B) The ventricular fractional shortening of 3 dpf erbb2 mutants is not significantly different from that of wild type (A). A ventricular fractional shortening defect manifests itself at -5 dpf (A) and an atrial fractional shortening defect appears at -10 dpf (B). Data are presented as mean ± s.d. ^*P<0.05. (C) erbb2 mutant hearts begin to develop bradycardia at <5 dpf. (D-G) Optical mapping of wild-type (D,F) and erbb2 mutant (E,G) hearts at 3 (D,E) and 10 (F,G) dpf. erbb2 mutants at 10 dpf (G) fail to develop the mature conduction system observed in their wild-type siblings (F).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	erbb2^st61/st61 erbb2^st61/st61; s878Tg
Observed In:	atrium cardiac conduction cardiac conduction system development cardiac ventricle
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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