FIGURE

Fig. 2

ID

ZDB-FIG-101104-34

Publication

Liu et al., 2010 - A dual role for ErbB2 signaling in cardiac trabeculation

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

ErbB2 signaling is essential for cardiac trabeculation in zebrafish. (A,B) Trabeculae start to form in wild-type larvae (A) at 3 dpf but are absent in erbb2 mutants (B). (C,D) The wild-type ventricle (C) is extensively trabeculated at 7 dpf, whereas trabeculae remain absent in erbb2 mutants (D) at the same stage. (E,F) Injection of an antisense morpholino oligonucleotide (MO) designed against erbb2 caused a significant reduction in cardiac trabecular formation (F), whereas a mismatch control MO had no effect (E). (G,H) Cardiac valve formation (arrows) appears to be unaffected in erbb2 mutants (H) compared with wild-type siblings (G).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	erbb2^st61/st61; s843Tg erbb2^st61/st61; twu26Tg s843Tg; s879Tg + MO1-erbb2
Knockdown Reagent:	MO1-erbb2
Observed In:	atrioventricular valve heart trabecula formation heart valve development myocardium trabecular layer
Stage Range:	Protruding-mouth to Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development