FIGURE

Fig. 8

ID

ZDB-FIG-101025-5

Publication

Larson et al., 2010 - Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation

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Fig. 8

Defects in oligodendrocyte number and patterning during the larval-to-adult transformation of puma mutants. (A, A′, B, B′) Wild-type zebrafish larvae exhibit many more plp+ oligodendrocytes in the brain than do puma mutants both during the middle larval period (A, A&prime& ~ 6.5 SSL) and the late larval period (B, B&prime& ~ 8.0 SSL). (C, C′, D, D′, E, E′) mbp expression also differs between wild-type and puma mutants during middle and later larval development (C, C′ and D, D′, respectively); a higher magnification view of different larvae is shown in E, E′. Note especially the absence of most myelinated fibers in the puma mutant and the concentration of mbp mRNA in cell bodies. (F, F′, G, G′) The early oligodendrocyte marker olig1 does not differ in expression between genotypes at middle or later larval stages, nor do several additional markers of particular cell lineages or activities (H–J; see text for details). Scale bars: in A, 100 μm, for A, A′, B, B′, C, C′, D, D′, F, F′. In E, 40 μm for E, E&prime& in G, 100 μm for G, G′ in H, 100 μm for H, H&prime& in J, 100 μm for I, J&prime& in J, 100 μm for J, K′.

Expression Data

Genes:	cnp mbpa olig1 plp1a reln
Fish:	WT tuba8l3^{j115e1/j115e1}
Anatomical Terms:	brain oligodendrocyte oligodendrocyte cell body oligodendrocyte cell projection
Stage Range:	Days 14-20 to Days 21-29

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tuba8l3^{j115e1/j115e1}
Observed In:	central nervous system myelination intracellular mRNA localization oligodendrocyte oligodendrocyte differentiation
Stage Range:	Days 14-20 to Days 21-29

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 346(2), Larson, T.A., Gordon, T.N., Lau, H.E., and Parichy, D.M., Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation, 296-309, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.