Gene
reln
- ID
- ZDB-GENE-020822-1
- Name
- reelin
- Symbol
- reln Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable hydrolase activity; lipoprotein particle receptor binding activity; and metal ion binding activity. Acts upstream of or within cerebellar Purkinje cell layer morphogenesis. Predicted to be located in extracellular region. Is expressed in immature eye and nervous system. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; familial temporal lobe epilepsy 7; and schizophrenia. Orthologous to human RELN (reelin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial temporal lobe epilepsy 7 | Alliance | {Epilepsy, familial temporal lobe, 7} | 616436 |
| Norman-Roberts syndrome | Alliance | Lissencephaly 2 (Norman-Roberts type) | 257320 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR002861 | Reeler domain |
| Domain | IPR041161 | Tenascin, EGF-like domain |
| Family | IPR034968 | Reelin |
| Homologous_superfamily | IPR036278 | Sialidase superfamily |
| Homologous_superfamily | IPR042307 | Reeler domain superfamily |
| Repeat | IPR049419 | Reelin, subrepeat B |
Domain Details Per Protein
| Protein | Length | EGF-like domain | Reeler domain | Reeler domain superfamily | Reelin | Reelin, subrepeat B | Sialidase superfamily | Tenascin, EGF-like domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:G1BJ50
|
3468 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available