FIGURE

Fig. 5

ID

ZDB-FIG-101021-5

Publication

Matsuda et al., 2010 - Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish

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Fig. 5

Knockdown of atoh1 function prevents loss of FGF signaling in the mib1 pLLp. (A,B) atoh1a and atoh1b knockdown prevents unregulated expansion of fgf10 expression in mib1 mutant (mib1^ta52b+atoh1MOs) zebrafish embryos (n=10/10) (A). It also prevents loss of fgfr1 expression (B). Statistical analysis is shown in Fig. S10A in the supplementary material. (C) dkk1 expression is recovered in mib1^ta52b+atoh1MOs embryos. For statistical analysis, see Fig. S11 in the supplementary material. (D) atoh1MOs allow partial recovery of cxcr7b expression in mib1^ta52b embryos (n=5/5). (E) atoh1MOs allow lef1 expression to expand further in mib1^m178 mutants. Statistical analysis is shown in Fig. S13 in the supplementary material. (F,G) Whereas there is no fgf3 expression in depositing (F) and deposited (G) neuromasts in wild-type (10/10) and mib1^m132 (10/10) embryos, knockdown of atoh1 results in the persistence of fgf3 expression in wild-type (7/10) and mib1^m132 (5/10) embryos.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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