FIGURE

Fig. S2

ID

ZDB-FIG-101021-10

Publication

Matsuda et al., 2010 - Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish

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Fig. S2

Knockdown of notch1a and notch3 together with DAPT treatment inhibits expression of the Notch target gene her4 in the pLLp. (A) her4 in the wild type. (B) her4 in mib1^ta52b mutant. (C) her4 in embryos treated with DAPT, a γ-secretase inhibitor. (D) notch1a and notch3 knockdown (N1a/N3MOs) results in a similar change in her4 expression. Partial inhibition of Notch signaling may paradoxically allow more cells to express her4 as its expression is also determined by proneural gene expression (Yeo et al., 2007) (data not shown). Expanded her4 expression may also result from loss of repression by additional HER factors, the expression of which is lost following DAPT treatment or N1a/N3 knockdown. (E) her4 was eliminated when embryos were treated with both DAPT and N1a/N3MOs (N1a/N3MO/DAPT).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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