FIGURE

Fig. 6

ID

ZDB-FIG-101007-8

Publication

Ramesh et al., 2010 - A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

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Fig. 6

Pathological changes were observed in G93R os10 spinal cord and muscle at the disease end-stage. (A) Electron microscopy of a spinal cord motoneuron from nTg sibling (left) and G93R os10 (right) adult end-stage fish. Numerous vacuolated mitochondria were observed in G93R os10 motoneurons (top) and were readily apparent at higher magnification (bottom). (B) Electron microscopy of trunk muscle from nTg sibling (left) and G93R os10 (right) fish also revealed severe abnormalities (top). The mitochondria in G93R os10 muscle also appeared to be affected, both in number and integrity, and cristae appeared to be reduced in number and lacked the normal organization (bottom). Bars, 2 μm (A,B; top panels); 150 nm (A,B; bottom panels).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	os10Tg
Observed In:	fast muscle cell mitochondrial crista fast muscle cell mitochondrion motor neuron mitochondrion skeletal muscle
Stage:	Adult

Phenotype Detail

Acknowledgments

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Full text @ Dis. Model. Mech.