FIGURE

Fig. 5

ID

ZDB-FIG-100603-30

Publication

Piloto et al., 2010 - Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration

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Fig. 5

Ovo1 and Wnt signaling regulate expression of genes involved in intracellular trafficking. (A) Real-time PCR in Ovo1 morphants reveals elevated expression levels of rab3c, rab12, rab11fip2 and sec6 mRNA levels (blue bars), compared with controls (red bars), whereas rab25 levels do not change. (B-E) In situ hybridization for expression of rab3c (B), rab12 (C), rab11fip2 (D) and sec6 (E) in NC cells (arrows) at 13 hpf. Lateral views, anterior to the left. e, eye. (F) Inhibition of Wnt signaling using heat-shock-inducible dnTCF (Tg(hs:dnTcf-GFP)w26) increases rab3c, rab11fip2 (indicated as fip2) and sec6 expression (blue bars), but not rab12, compared with wild-type siblings (red bars). *, P≤0.05; **, P≤0.01.

Expression Data

Genes:	exoc3l2b rab3c rab11fip2 rab12 rab25a
Fish:	WT WT + MO2-ovol1a w26Tg/+
Knockdown Reagent:	MO2-ovol1a
Anatomical Terms:	neural crest whole organism
Stage:	5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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