FIGURE

Fig. S8

ID

ZDB-FIG-091221-26

Publication

Song et al., 2009 - Mechanisms Underlying Metabolic and Neural Defects in Zebrafish and Human Multiple Acyl-CoA Dehydrogenase Deficiency (MADD)

Other Figures

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Fig. S8

xav mutants exhibit aberrant mitochondria distribution in motor neurons. A–B. Mito-GFP was expressed in motor neurons and branching and synapse formation followed over time. In WT embryos at ∼56 hpf, mitochondria are distributed along the entire axon. Mitochondria are continuously added over time, increasing both in number and density. In contrast, in xav mutants, while the number and distribution of mitochondria clusters along the axon are comparable to WT embryos at ∼56 hpf, the continuous addition of mitochondria is absent, resulting in a decrease of mitochondria cluster density by 3 dpf. N = 9–10 embryos, 3–4 carrier pairs. Scale bar = 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	etfdh^p6di/p6di
Observed In:	motor neuron mitochondrion
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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