FIGURE

Fig. S9

ID

ZDB-FIG-091221-25

Publication

Song et al., 2009 - Mechanisms Underlying Metabolic and Neural Defects in Zebrafish and Human Multiple Acyl-CoA Dehydrogenase Deficiency (MADD)

Other Figures

All Figure Page

Back to All Figure Page

Fig. S9

xav mutants exhibit cell death throughout the nervous system that is rescued by p53 morpholino knockdown and does not account for the motor axon branching, neuromuscular synapse or motility defects. A. xav mutants exhibit widespread cell death in the peripheral and central nervous system. There was a dramatic increase in TUNEL+cells in xav mutants compared to WT embryos at ∼56–72 hpf, particularly in the retina and spinal cord. B. At 56 hpf, cell death was blocked using a morpholino against p53. However, blocking cell death did not block the reduction of axon branching and synaptogenesis phenotypes that are present in xav mutants. N>6 embryos, 2 carrier pairs. Scale bar = 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	etfdh^p6di/p6di etfdh^p6di/p6di + MO4-tp53
Knockdown Reagent:	MO4-tp53
Observed In:	motor neuron axon motor neuron axon terminus neuron apoptotic process
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One