FIGURE

Fig. 2

ID

ZDB-FIG-091215-2

Publication

Yanicostas et al., 2009 - Anosmin-1a is required for fasciculation and terminal targeting of olfactory sensory neuron axons in the zebrafish olfactory system

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Fig. 2

Effects of anosmin-1a depletion on the differentiation of the olfactory epithelium and axon pathfinding of olfactory sensory neurons. Frontal views of living omp-tau::GFP zebrafish embryos at 24 (A–E), 48 (F–J) and 72 hpf (K–O). Wild-type embryos (A, F, K) and kal1a morphants (B–E, G–J, L–O). The same wild-type embryo (A, F, K) and kal1a morphants (B, G, L; C, H, M; D, I, N and E, J, O) were visualized at 24, 48, and 72 hpf. Dorsal is to the top, and ventral to the bottom. Large white arrow indicates tightly fasciculated OSN axons, small white arrows show defasciculated axon fibres within olfactory bulbs, red arrows indicate disorganized olfactory sensory axons and small green arrows point to dissociated olfactory sensory neurons. OE, olfactory epithelium; ON, olfactory nerve; OB, olfactory bulbs. Scale bar = 50 μm.

Expression Data

Gene:	EGFP
Fish:	jt0012Tg jt0012Tg + MO2-anos1a
Knockdown Reagent:	MO2-anos1a
Anatomical Terms:	olfactory receptor cell olfactory receptor cell axon
Stage Range:	Prim-5 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	jt0012Tg + MO2-anos1a
Knockdown Reagent:	MO2-anos1a
Observed In:	axon guidance fasciculation of sensory neuron axon innervation olfactory bulb olfactory bulb development olfactory epithelium olfactory placode olfactory receptor cell olfactory receptor cell axon
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Molecular and Cellular Endocrinology, 312(1-2), Yanicostas, C., Herbomel, E., Dipietromaria, A., and Soussi-Yanicostas, N., Anosmin-1a is required for fasciculation and terminal targeting of olfactory sensory neuron axons in the zebrafish olfactory system, 53-60, Copyright (2009) with permission from Elsevier. Full text @ Mol. Cell. Endocrinol.