FIGURE

Fig. 4

ID

ZDB-FIG-090717-17

Publication

Lamont et al., 2009 - Antagonistic interactions among Plexins regulate the timing of intersegmental vessel formation

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Fig. 4

Loss of plxnD1 and sema3e/plxnB2 results in an intermediate angioblast sprouting phenotype (A) Graphical representation of the mean number and standard deviation of angioblast sprouts observed in plxnB2^i10e11/obd morphants as compared to control obd mutant embryos. (B) Graphical representation of the proportion of embryos exhibiting a given number of ISVs sprouts in uninjected obd wt sibs, sema3e^ATG MO/obd wt sib morphants, uninjected obd mutant embryos, and sema3e^ATG MO/obd morphants. (C–F) Confocal images of uninjected obd mutant (C), uninjected wt sibs (D), plxnB2^i10e11/obd morphants (E), and sema3e^ATG/obd morphants (F) at 24 hpf on a Tg(kdr:GFP)^la116 genetic background. Scale bars in (C–F) are 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	la116Tg + MO1-plxnb2a.1 la116Tg + MO1-sema3e
Knockdown Reagents:	MO1-plxnb2a.1 MO1-sema3e
Observed In:	axial vasculature intersegmental vessel sprouting angiogenesis
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 331(2), Lamont, R.E., Lamont, E.J., and Childs, S.J., Antagonistic interactions among Plexins regulate the timing of intersegmental vessel formation, 199-209, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.