FIGURE

Fig. 6

ID

ZDB-FIG-090408-66

Publication

Borodovsky et al., 2009 - Neural protein Olig2 acts upstream of the transcriptional regulator sim1 to specify diencephalic dopaminergic neurons

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Fig. 6

Loss of olig2 gene function affects the expression of sim1. A,B: Embryos injected with olig2 MO were subjected to whole mount in situ hybridization with antisense sim1 RNA probe (purple), followed by immuno-staining with anti-TH antibody to detect DA neurons (brown). C,D: Embryos injected with sim1 MO were subjected to whole mount in situ hybridization with olig2 RNA probe (purple). Black arrowhead marks deficient Sim1 expression domain in the PT. All images are presented in lateral view, anterior to the left. NPO, neurosecretory preoptic area; PT, posterior tuberculum; Tel, telencephalon; Tha, thalamus. Scale bar = 50 μm.

Expression Data

Genes:	olig2 sim1a
Fish:	TL TL + MO1-olig2 TL + MO3-sim1a + MO4-sim1a
Knockdown Reagents:	MO1-olig2 MO3-sim1a MO4-sim1a
Anatomical Terms:	caudal tuberculum preoptic area thalamus
Stage Range:	Prim-25 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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