FIGURE

Fig. 4

ID

ZDB-FIG-090224-49

Publication

Dowling et al., 2009 - Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Abnormal perinuclear ultrastructure in 72 hpf myotubularin morphants.

Comparison of the perinuclear area from control (CTL MO) and myotubularin (MTM MO) morphants. (A, B) Control injected embryos had thin myonuclei (N) with well organized perinuclear organelles (M = mitochondria). Myotubularin injected embryos had large, rounded nuclei (N) and disorganized perinuclear compartments. Three embryos from three independent injections were examined. Higher magnification (C, D) of the perinuclear compartment revealed abnormal mitochondria (M), areas nearly devoid of organelles (**), and several tubule-like structures (arrows). (E) Example of an unusual membranous perinuclear structure. Such structures were observed in multiple myofibers. Scale bars: A, B (2 mm), C–E (500 nm).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-mtm1
Knockdown Reagent:	MO1-mtm1
Observed In:	skeletal muscle cell mitochondrion skeletal muscle cell nucleus skeletal muscle cell perinuclear region of cytoplasm
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.