FIGURE

Fig. 3

ID

ZDB-FIG-090224-48

Publication

Dowling et al., 2009 - Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy

Other Figures

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Fig. 3

Abnormal histopathology in 72 hpf myotubularin morphants.

(A) H/E stained longitudinal myofibers from myotubular myopathy (MTM) and age matched control (CTL) human muscle biopsies. Arrows point to abnormal nuclei. (B) H/E stained longitudinal myofibers from control (CTL MO) and myotubularin (MTM MO) morphant 72 hpf embryos. Myonuclei are abnormally rounded (arrows), and there is increased space between fibers (*). (C) Toluidine blue stained semi-thin sections from 72 hpf morphants. Myonuclei from myotubularin morphants are large, abnormally rounded, and contain discrete nucleoli (arrows). Sarcomeric units, however, are normal in appearance. Scale bar = 20 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-mtm1
Knockdown Reagent:	MO1-mtm1
Observed In:	skeletal muscle cell skeletal muscle cell nucleus
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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