FIGURE

Fig. 5

ID

ZDB-FIG-081003-17

Publication

Luo et al., 2008 - Nr4a2 is essential for the differentiation of dopaminergic neurons during zebrafish embryogenesis

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Fig. 5

Knockdown of Nr4a2 results in the increase of nr4a2b⁺ cells and the inhibition of DA neuron differentiation. (A and B) In the embryos injected with nr4a2^mo, the number of nr4a2b⁺ cells (black) is increased while the number of TH⁺ neurons is decreased (red) (white arrows). (C) Bar scale to show that the number of nr4a2b⁺ cells (red) in nr4a2^mo is increased by 57.5% (p = 0.0172) compared to 5-mm injected embryos. (D) BrdU incorporation and TUNEL assay to show that there is no obvious cell proliferation or apoptosis in the PT area. White rectangles show the position of the PT area between two eyeballs as the dashed lines show.

Expression Data

Genes:	nr4a2b th
Fish:	WT WT + MO2-nr4a2a,nr4a2b
Knockdown Reagent:	MO2-nr4a2a,nr4a2b
Anatomical Term:	forebrain
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-nr4a2a,nr4a2b
Knockdown Reagent:	MO2-nr4a2a,nr4a2b
Observed In:	forebrain adrenergic neuron forebrain neuron development
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Molecular and cellular neurosciences, 39(2), Luo, G.R., Chen, Y., Li, X.P., Liu, T.X., and Le, W.D., Nr4a2 is essential for the differentiation of dopaminergic neurons during zebrafish embryogenesis, 202-210, Copyright (2008) with permission from Elsevier. Full text @ Mol. Cell Neurosci.