Fig. 1
- ID
- ZDB-FIG-081003-13
- Publication
- Luo et al., 2008 - Nr4a2 is essential for the differentiation of dopaminergic neurons during zebrafish embryogenesis
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Distribution of nr4a2b transcripts throughout the early developmental stages of zebrafish embryos. Anterior is to the left and dorsal is up. (A–D) nr4a2b is a maternal expressed gene and is universally expressed from 0.75 hpf to 12 hpf stage. (E) The first specific transcripts are found in brain at about the stage of 18 hpf (white arrows). (F) Two groups of nr4a2b+ cells appear at 24 hpf. One is near OB in tel (black heads), and the other is around the rh (white arrowheads). A group of nr4a2b+ cells emerges in PT (white arrows). (G–J) The nr4a2b+ cells in PT area (white arrows) and in tg (black arrows in the lateral view) are expanded from 30 hpf to 120 hpf. At the stage of 48–120 hpf, nr4a2b transcripts display a complex pattern (I and J). It is expressed at MO (black arrows in the dorsal review) and ret (black arrowheads). MO, medulla oblongata; OB, olfactory bulb; PT, posterior tuberculum; rh, rhombencephalon; ret, retina; tel, telencephalon; tg, tegmentum. |
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| Stage Range: | 2-cell to Day 5 |
Reprinted from Molecular and cellular neurosciences, 39(2), Luo, G.R., Chen, Y., Li, X.P., Liu, T.X., and Le, W.D., Nr4a2 is essential for the differentiation of dopaminergic neurons during zebrafish embryogenesis, 202-210, Copyright (2008) with permission from Elsevier. Full text @ Mol. Cell Neurosci.