FIGURE

Fig. S6

ID

ZDB-FIG-080925-13

Publication

Del Bene et al., 2008 - Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient

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Fig. S6

Phenocopy of moks³⁰⁹ Phenotype by Morpholino Knockdown of Dynactin-1 Function
(A-C) Retina sections of 5 dpf embryos injected with splicing morpholino against dynactin-1 gene (dnct1Mo) or control morpholino (ctrlMo). Dnct1Mo injection resulted in a mild (B) or severe phenotyope (C) overall resembling the mok^s309 phenotype in thickening of the GCL (B,C) and disruption of ONL (C).
(D, E) Absence of opsin-GFP localization in dnct1Mo injected embryos was observed in the transgenic line expressing a GFP fused to the C-terminal 44 amino acids of Xenopus rhodopsin, in a subset of photoreceptors (Perkins et al., 2002). When GFP signal was detected in the injected embryos it was mislocalized around the nucleus as well as in the photoreceptor outer segment (E′) as reported in mok (Doerre and Malicki, 2001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + MO2-dctn1a
Knockdown Reagent:	MO2-dctn1a
Observed In:	retinal ganglion cell layer retinal ganglion cell retinal photoreceptor layer photoreceptor cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Cell, 134(6), Del Bene, F., Wehman, A.M., Link, B.A., and Baier, H., Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient, 1055-1065, Copyright (2008) with permission from Elsevier. Full text @ Cell