FIGURE
Fig. 7
- ID
- ZDB-FIG-080505-52
- Publication
- Hawkins et al., 2008 - The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish
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Fig. 7
Inhibition of the FGF pathway by SU5402 does not show any similarities to U0126-treated embryos. A-C: Expression of the Fgf-pathway target gene sef is downregulated in SU5402 (C) but not in U0126-treated (B) embryos. D-I: Expression of the notochordal marker genes col2a1 (D-F) and shh (G-I) also show different defects in SU5402 and U0126-treated embryos. J-M: Expression of lox1 (J, K) and lox5b (L-M) is not decreased normally by U0126-treatment. N, O: copa mRNA persists and is not downregulated by U0126-treatment. |
Expression Data
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| Stage: | Prim-5 |
Expression Detail
Antibody Labeling
Phenotype Data
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| Conditions: | |
| Observed In: | |
| Stage: | Prim-5 |
Phenotype Detail
Acknowledgments
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Full text @ BMC Dev. Biol.