FIGURE

Fig. 6

ID

ZDB-FIG-080325-67

Publication

Kinkel et al., 2008 - Cdx4 is required in the endoderm to localize the pancreas and limit {beta}-cell number

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Fig. 6

Cdx4 functions in the endoderm to localize the pancreas. (A,C,E) Cell transplantation strategy. Donor and host zebrafish embryos were injected at the one-cell stage with the indicated reagents. At the sphere stage, donor cells were transplanted to host blastoderm margin. (B) cdx4 knockdown in endoderm is sufficient to shift the pancreas posteriorly. (D) Wild-type endoderm rescues the pancreas location in a cdx4-knockdown host. (F) Cdx4 overexpression in endoderm results in insulin expression anterior to the normal pancreatic domain. Embryos at 24hpf, dorsal view. Magnification: 100x.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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