FIGURE

Fig. 5

ID

ZDB-FIG-080325-66

Publication

Kinkel et al., 2008 - Cdx4 is required in the endoderm to localize the pancreas and limit {beta}-cell number

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Fig. 5

Cdx4 and Cdx1a function redundantly. (A-D) The pdx1 domain is further expanded in zebrafish kgg mutants and siblings following morpholino (MO) knockdown of cdx1a. (E-H) The insulin domain is further expanded, and β-cells show a delay in converging to form the islet, following cdx1a knockdown in kgg mutants and siblings. Numbers indicate somites. Dorsal views. Magnification: 200x.

Expression Data

Genes:	ins pdx1
Fish:	cdx4^hi2188aTg/+ + MO1-cdx1a cdx4^{hi2188aTg/hi2188aTg} + MO1-cdx1a
Knockdown Reagent:	MO1-cdx1a
Anatomical Terms:	gut pancreas primordium pancreatic B cell pancreatic bud posterior pancreatic bud
Stage Range:	20-25 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cdx4^hi2188aTg/+ + MO1-cdx1a cdx4^{hi2188aTg/hi2188aTg} + MO1-cdx1a
Knockdown Reagent:	MO1-cdx1a
Observed In:	anterior/posterior pattern specification cell migration pancreas development pancreas primordium pancreatic bud
Stage Range:	20-25 somites to Prim-5

Phenotype Detail

Acknowledgments

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