FIGURE

Fig. 4

ID

ZDB-FIG-070925-20

Publication

Varga et al., 2007 - Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo

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Fig. 4

chordin expression is required for otx2 expression and suppresses foxi1 expression in 10 hpf embryos inhibited in expression of both β-catenins. Untreated ich embryos (A and D) and ich embryos injected with βcat1MO and βcat2MO ([MO1 + MO2] (B and E), or additionally with chdMO (C and F) were assayed for expression of otx2 (A–C) or foxi1 (D–F). Inhibition of expression of the two β-catenins results in induction of the anterior neural marker otx2 at the expense of expression of the epidermal marker foxi1. The inhibition of Chd in such embryos prevents otx2 expression and restores the foxi1 expression. Concentrations of MOs injected were as in Fig. 3 and embryos are shown in lateral views.

Expression Data

Genes:	foxi1 otx2b
Fish:	brs^b2; ctnnb2^p1/p1 brs^b2; ctnnb2^p1/p1 + MO1-ctnnb2 + MO2-ctnnb1 brs^b2; ctnnb2^p1/p1 + MO1-chrd + MO1-ctnnb2 + MO2-ctnnb1
Knockdown Reagents:	MO1-chrd MO1-ctnnb2 MO2-ctnnb1
Anatomical Terms:	unspecified whole organism
Stage:	Bud

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 124(9-10), Varga, M., Maegawa, S., Bellipanni, G., and Weinberg, E.S., Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo, 775-791, Copyright (2007) with permission from Elsevier. Full text @ Mech. Dev.