FIGURE

Fig. 8

ID

ZDB-FIG-070307-76

Publication

Hans et al., 2007 - Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b

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Fig. 8

Ectopic foxi1 expression after treatment with retinoic acid (RA) results in ectopic Fgf-dependent otic induction. (A, B, E, F) In comparison to wild-type control embryos treated with DMSO, embryos treated with 20nM RA show ectopic pax8 and foxi1 expression surrounding the anterior neural plate border without affecting the neural expression of otx2. (C, G) In fgf3, fgf8 double mutants, pax8 is completely abolished in the control embryos, whereas RA-treated double mutant embryos show weak anterior expression of pax8. (D, H) In foxi1 mutants treated with DMSO, pax8 expression can not be detected in the preotic region; but in foxi1 mutants treated with RA, residual anterior pax8 expression is present. Dorsal views of 1–3-somite stage embryos with anterior towards the top. Scale bar: 40 μm.

Expression Data

Genes:	foxi1 otx2b pax8
Fish:	WT foxi1^em1/em1 fgf3^{t24149/t24149}; fgf8a^{ti282a/ti282a}
Condition:	chemical treatment: all-trans-retinoic acid
Anatomical Terms:	neural keel otic placode
Stage:	1-4 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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