Fig. 8
Telencephalic progenitors express sox2 and have molecular characteristics of glia. (A–B) Comparison of BrdU incorporation (red) after 4 h tracing with the expression of sox2 (A–A″) or fabp7a (B) (blue, in situ hybridization). Cross-sections, dorsal up. Telencephalic progenitors are found in the expression domain of both markers. (C–E) Analysis in confocal microscopy (thickness 2 μm) of BLBP protein (green) and BrdU incoporation (red) after 4 h (C), 3 days (D) or 2 weeks (E). Examples of cells positive only for BrdU are indicated by red arrows, examples of cells doubly positive by yellow arrows. (F) Percentage of BLBP-positive cells that are also BrdU-positive after progressively longer tracing times. Note that this number strikingly decreases over time. |
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Reprinted from Developmental Biology, 295(1), Adolf, B., Chapouton, P., Lam, C.S., Topp, S., Tannhauser, B., Strähle, U., Gotz, M., and Bally-Cuif, L., Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon, 278-293, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.