FIGURE

Fig. 8

ID

ZDB-FIG-060726-9

Publication

Brand et al., 1996 - Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain

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Fig. 8

Expression of MHB markers is affected in ace embryos. Shown are lateral views of wild-type (left) and ace mutant (right) embryos. Arrows point to the posterior border of the tectum. (A,B) eng protein (dark brown staining around the MHB) is not detected in the tectum, tegmentum and cerebellum of 28 h ace mutant embryos. (C,D) pax-b expression is missing in the posterior midbrain of 24 h ace mutant embryos, but is unaffected elsewhere. (E,F) wnt1 expression is not found in the posterior tectum of 26 h ace mutant embryos. Notice the extension of the wnt1 stripe in the dorsal tectum to more posterior levels. Expression in the rhombomeres (arrowheads) is not affected. (G,H) Expression of Zash1A in the tectal ventricular zone (arrowhead) is strongly increased in the mutant embryo compared to its sibling at 26 h. Stainings of the embryos in G and H were done in the same vial. Scale bar, 90 µm.

Expression Data

Genes:	ascl1a pax2a wnt1
Antibody:	Ab1-eng
Fish:	WT fgf8a^{ti282a/ti282a}
Anatomical Terms:	cerebellum midbrain posterior region optic tectum optic tectum posterior region optic tectum ventricular zone tegmentum
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgf8a^{ti282a/ti282a}
Observed In:	cerebellum midbrain hindbrain boundary optic tectum tegmentum
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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