Gene
wnt1
- ID
- ZDB-GENE-980526-526
- Name
- wingless-type MMTV integration site family, member 1
- Symbol
- wnt1 Nomenclature History
- Previous Names
-
- int-1
- etID22400.23 (1)
- sb:eu647
- zgc:194464
- zgc:194478
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have frizzled binding activity. Involved in brain development. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15 and osteoporosis. Is expressed in several structures, including central nervous system; midbrain hindbrain boundary neural keel; neural plate; neural rod; and neural tube. Orthologous to human WNT1 (Wnt family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 116 figures from 83 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu647 (26 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteogenesis imperfecta type 15 | Alliance | Osteogenesis imperfecta, type XV | 615220 |
| {Osteoporosis, early-onset, susceptibility to, autosomal dominant} | 615221 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Wnt | Wnt-1 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B987
|
375 | ||||
|
UniProtKB:B3DI55
|
370 | ||||
|
UniProtKB:P24257
|
370 |
Interactions and Pathways
No data available
Plasmids