FIGURE

Fig. 8

ID

ZDB-FIG-060201-8

Publication

Hamade et al., 2006 - Retinoic acid activates myogenesis in vivo through Fgf8 signalling

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Fig. 8

Repression and activation, respectively, of fgf8 expression by DEAB and RA. 10-somite stage embryos, oriented as in Fig. 2. (A) fgf8 is expressed in tailbud, anterior psm and anterior aspect of somites; expression in somites decreases as somites maturate. (B) In nls embryos, fgf8 expression is overall reduced. (C) In DEAB-treated embryos, fgf8 is strongly reduced in anterior psm (bracket) and somites. (D) In RA-treated embryos, fgf8 expression is increased in anterior psm (bracket). (E) Blocking of translation by prior incubation in cycloheximide (CHX/RA) does not prevent fgf8 activation by RA in psm (bracket). Scale bar: in panel A, 100 μm for panels A–F.

Expression Data

Gene:	fgf8a
Fish:	WT aldh1a2^i26/i26
Conditions:	chemical treatment: cycloheximide chemical treatment: cycloheximide chemical treatment by environment: 4-(diethylamino)benzaldehyde chemical treatment: all-trans-retinoic acid
Anatomical Terms:	segmental plate somite tail bud
Stage:	10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 289(1), Hamade, A., Deries, M., Begemann, G., Bally-Cuif, L., Genet, C., Sabatier, F., Bonnieu, A., and Cousin, X., Retinoic acid activates myogenesis in vivo through Fgf8 signalling, 127-140, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.