FIGURE

Fig. 6

ID

ZDB-FIG-050228-20

Publication

Ninkovic et al., 2005 - Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair

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Fig. 6

The activity of both Her5 and Him is necessary to prevent neurogenesis in the lateral IZ. Dorsal views of flat-mounted -8.4ngn1::egfp transgenic embryos (Blader et al., 2003) probed at the three-somite stage for egfp expression (blue) after injection of 1 mM her5MO^ATG + 0.25 mM himGripNA^ATG (A), 1 mM her5MO^ATG (B), 0.25 mM himGripNA^ATG (C), compared to an uninjected control (D). A' and D' are enlargements of the boxed areas in A and D, respectively. The IZ is indicated by pax2.1 expression (red staining). Note that the LIZ is undergoing ectopic neurogenesis only in the embryo injected with both her5MO^ATG and himGripNA^ATG (blue arrows).

Expression Data

Gene:	pax2a
Fish:	AB AB + MO1-her5
Knockdown Reagent:	MO1-her5
Anatomical Term:	unspecified
Stage:	1-4 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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