FIGURE SUMMARY
Title

Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models

Authors
Zhu, X.Y., Guo, D.W., Lao, Q.C., Xu, Y.Q., Meng, Z.K., Xia, B., Yang, H., Li, C.Q., Li, P.
Source
Full text @ Sci. Rep.
Figure 1

Cancer cell proliferations were suppressed after 48-h drug treatment in the zebrafish xenotransplanted with human A549 non-small-cell lung cancer cells, human SGC-7901 stomach cancer cells, human HepG2 liver cancer cells, human JF 305 pancreatic cancer cells, and human MCF-7 breast cancer cells. a1, b1, c1, d1 and e1 were the control xenotransplanted zebrafish without drug treatment. a2–a6 were treated with Bevacizumab, cis-Platinum, Endostar, Paclitaxel and Vinorelbine; b2–b6 were treated with 5-FU, Hydroxyurea, cis-Platinum, Irinotecan and Paclitaxel; c2–c6 were treated with Adriamycin, Gemcitabine, Hydroxyurea, cis-Platinum and 5-FU; and d2–d4 as well as e2–e4 were treated with Furanodiene at concentrations of 1/9 MTC, 1/3 MTC and MTC, respectively. A representative entire body of the xenotransplanted zebrafish body was shown in f.
Figure 2

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Figure 3

Synergistic anti-cancer effects of Furanodiene with 5-FU in zebrafish xenotransplanted with human BEL-7402 liver cancer cells (above) or with human MDA-MB-231 breast cancer cancer cells (below).
Figure 4

Sensitizing effect of Furanodiene on cis-Platinum-resistant human A549 non-small-cell lung cancer cells (above) and Adriamycin-resistant MCF-7 breast cancer cells (below) xenotransplanted into zebrafish.
Figure 5

Apoptosis in zebrafish treated with cis-Platinum or Adriamycin alone, and cis-Platinum or Adriamycin in combination with Furanodiene at 1/9 MTC, 1/3 MTC and MTC, respectively (a). Quantitative data of (a) were shown in (b).
Figure 6

DNA single strand breaks (above) and DNA double strand breaks (below) in zebrafish treated with Furanodiene at 1/9 MTC, 1/3 MTC and MTC. H2O2 was used as a positive control.
Figure 7

Pgp efflux transporter regulation in zebrafish treated with Furanodiene. (a) Pgp function inhibition by Furanodiene at 1/9 MTC, 1/3 MTC and MTC, 1 mM Verapamil was used as a positive control; (b) Pgp gene expression analyses by PCR; and (c) Pgp protein assay by Western blot.

EXPRESSION / LABELING:
Gene:
Fish:
Conditions:
Anatomical Term:
Stage: Prim-15
Table 3

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

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Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.
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