FIGURE

Figure 1

ID

ZDB-FIG-190723-1127

Publication

Zhu et al., 2019 - Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models

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Figure 1

Cancer cell proliferations were suppressed after 48-h drug treatment in the zebrafish xenotransplanted with human A549 non-small-cell lung cancer cells, human SGC-7901 stomach cancer cells, human HepG2 liver cancer cells, human JF 305 pancreatic cancer cells, and human MCF-7 breast cancer cells. a1, b1, c1, d1 and e1 were the control xenotransplanted zebrafish without drug treatment. a2–a6 were treated with Bevacizumab, cis-Platinum, Endostar, Paclitaxel and Vinorelbine; b2–b6 were treated with 5-FU, Hydroxyurea, cis-Platinum, Irinotecan and Paclitaxel; c2–c6 were treated with Adriamycin, Gemcitabine, Hydroxyurea, cis-Platinum and 5-FU; and d2–d4 as well as e2–e4 were treated with Furanodiene at concentrations of 1/9 MTC, 1/3 MTC and MTC, respectively. A representative entire body of the xenotransplanted zebrafish body was shown in f.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	cancer xenotransplantation, chemical treatment: 5-fluorouracil cancer xenotransplantation, chemical treatment: doxorubicin cancer xenotransplantation cancer xenotransplantation, chemical treatment: cisplatin cancer xenotransplantation, chemical treatment: Furanodiene cancer xenotransplantation, chemical treatment: gemcitabine cancer xenotransplantation, chemical treatment: hydroxyurea cancer xenotransplantation, chemical treatment: irinotecan cancer xenotransplantation, chemical treatment: paclitaxel cancer xenotransplantation, chemical treatment: vinorelbine
Observed In:	whole organism neoplasm
Stage:	Day 6

Phenotype Detail

Acknowledgments

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