- Title
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Fli1 Acts at the Top of the Transcriptional Network Driving Blood and Endothelial Development
- Authors
- Liu, F., Walmsley, M., Rodaway, A., and Patient, R.
- Source
- Full text @ Curr. Biol.
Upregulation of Blood and Endothelial Markers by Fli1-VP16 WISH of zebrafish 10 s stage embryos injected with Fli1 or Fli1-VP16. In whole-mounted embryos, head to top, focusing on PLM (G–M). In flat-mounted embryos, head to top (A–F, M–R) or to left (S, T). Red arrows indicate expanded expression. EXPRESSION / LABELING:
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Fli1 May Act in Parallel with Cloche but Upstream of Scl and Etsrp (A–J) WISH on wild-type or Cloche mutant zebrafish embryos injected with combinations of Fli1-VP16 mRNA and/or Scl/Etsrp MOs. 10 s stage, dorsal view, head to top. (K) A genetic regulatory network linking Bmp to Fli1 at the top of the hemangioblast hierarchy, drawn according to Davidson et al. [29]. Solid lines, direct regulation; dashed lines, no evidence for direct or indirect. Evidence for links quoted in text, apart from Gata2 as a direct Bmp target [32]. EXPRESSION / LABELING:
PHENOTYPE:
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Fli1 expression in the PLM is independent of Cloche at an early stage. EXPRESSION / LABELING:
PHENOTYPE:
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Loss- and gain-of function experiments reveal differential control of Fli1 expression by BMP signalling. EXPRESSION / LABELING:
PHENOTYPE:
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