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Fig. 4 Fli1 May Act in Parallel with Cloche but Upstream of Scl and Etsrp
(A–J) WISH on wild-type or Cloche mutant zebrafish embryos injected with combinations of Fli1-VP16 mRNA and/or Scl/Etsrp MOs. 10 s stage, dorsal view, head to top.
(K) A genetic regulatory network linking Bmp to Fli1 at the top of the hemangioblast hierarchy, drawn according to Davidson et al. [29]. Solid lines, direct regulation; dashed lines, no evidence for direct or indirect. Evidence for links quoted in text, apart from Gata2 as a direct Bmp target [32].
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