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Phenotype Figure Summary
Marker:
atxn7
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Thyme
et al.
, 2019
Fig. 2
atxn7
a236/a236
prepulse inhibition increased magnitude, abnormal
response to absence of light increased process quality, abnormal
startle response decreased magnitude, abnormal
swimming decreased linear velocity, abnormal
swimming decreased spatial extent of a process, abnormal
swimming increased frequency, abnormal
Fig. S4
atxn7
a236/a236
prepulse inhibition increased magnitude, abnormal
response to absence of light increased process quality, abnormal
startle response decreased magnitude, abnormal
swimming decreased linear velocity, abnormal
swimming decreased spatial extent of a process, abnormal
swimming increased frequency, abnormal
Carrillo-Rosas
et al.
, 2018
Fig. 2
AB + MO3-atxn7
, 
AB + MO1-atxn7
optic cup unfused from optic cup, abnormal
optic fissure closure incomplete, abnormal
posterior segment eye proximal side irregularly shaped, abnormal
posterior segment eye proximal side lacks parts or has fewer parts of type retinal pigmented epithelium, abnormal
retinal pigmented epithelium decreased area, abnormal
Fig. 3
AB + MO1-atxn7
optic fissure open, abnormal
retinal neural layer protruding into brain, abnormal
Fig. 5
AB + CRISPR1-atxn7
optic cup unfused from optic cup, abnormal
optic fissure closure incomplete, abnormal
retinal pigmented epithelium incomplete structure, abnormal
Fig. 6
AB + MO1-atxn7
diencephalon
pax6a
expression mislocalised, abnormal
diencephalon
shha
expression increased amount, abnormal
floor plate
shhb
expression increased amount, abnormal
forebrain ventral region
shhb
expression increased amount, abnormal
optic cup ventral region
vax2
expression increased distribution, abnormal
optic stalk
pax2a
expression increased distribution, abnormal
optic vesicle
pax2a
expression mislocalised, abnormal
optic vesicle posterior region
pax6a
expression mislocalised, abnormal
telencephalon
vax2
expression mislocalised, abnormal
Fig. 7
cu2Tg; jh1Tg; q20Tg + MO1-atxn7
cranial nerve II axon guidance disrupted, abnormal
cranial nerve II axonal fasciculation disrupted, abnormal
cranial nerve II misrouted, abnormal
optic nerve head fasciculation, abnormal
Fig. 8
AB + MO1-atxn7
camera-type eye photoreceptor cell differentiation disrupted, abnormal
photoreceptor cell photoreceptor inner segment malformed, abnormal
photoreceptor cell photoreceptor outer segment absent, abnormal
photoreceptor cell photoreceptor outer segment decreased length, abnormal
retina
crx
expression decreased distribution, abnormal
retina
crx
expression spatial pattern, abnormal
retinal pigmented epithelium decreased pigmentation, abnormal
text only
AB + MO1-atxn7
eye decreased diameter, abnormal
histone H2B conserved C-terminal lysine deubiquitinase activity disrupted, abnormal
somite morphology, abnormal
whole organism decreased length, abnormal
Yanicostas
et al.
, 2012
Fig. 3
AB + MO1-atxn7
, 
AB + MO2-atxn7
embryo development disrupted, abnormal
whole organism dead, abnormal
whole organism deformed, abnormal
Fig. 4
AB + MO2-atxn7
photoreceptor cell decreased amount, abnormal
photoreceptor cell differentiation disrupted, abnormal
retinal photoreceptor layer disorganized, abnormal
Fig. 5
AB + MO2-atxn7
Purkinje cell decreased amount, abnormal
Fig. 6
AB + MO2-atxn7
cerebellar granule cell decreased amount, abnormal
cerebellar Purkinje cell differentiation disrupted, abnormal
Purkinje cell decreased amount, abnormal
Fig. S3
AB + MO2-atxn7
cerebellar Purkinje cell differentiation disrupted, abnormal
Purkinje cell decreased amount, abnormal
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