| ZFIN ID: ZDB-EXP-241217-14 |
Experiment Conditions Description: chemical treatment by environment: diazoxide, primary cell culture: bulbus arteriosus
| chemical treatment by environment: diazoxide |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | diazoxide |
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| Synonyms: | 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide, Diazossido, diazoxide, diazoxido, diazoxidum, Eudemine |
| Definition: | A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies. |
| Ontology: | ChEBI [CHEBI:4495] ( EBI ) |
| primary cell culture: bulbus arteriosus |
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| Name: | primary cell culture |
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| Synonyms: | |
| Definition: | In vitro culture condition in which an embryo or adult fish is dissociated to a single cell suspension. The analysis is made on this cell culture. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000145] |
| Name: | bulbus arteriosus |
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| Synonyms: | cardiac outflow tract, outflow tract, truncus |
| Definition: | Multi-tissue structure that consists of three layers and through which the blood exits the heart. The bulbus arteriosus is a pear shaped chamber that functions as a capacitor, maintaining continuous blood flow into the gill arches. |
| Ontology: | Anatomy Ontology [ZFA:0000173] |
| Publication: | Singareddy et al., 2021 |
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