Search Ontology:
ChEBI
diazoxide
- Term ID
- CHEBI:4495
- Synonyms
-
- 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
- Diazossido
- Diazoxide
- diazoxido
- diazoxidum
- Eudemine
- Definition
- A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
- References
-
- CAS:364-98-7
- DrugBank:DB01119
- Drug_Central:854
- HMDB:HMDB0015251
- KEGG:C06949
- KEGG:D00294
- LINCS:LSM-3639
- PMID:11014217
- PMID:12039709
- PMID:15319354
- PMID:16740260
- PMID:16777075
- PMID:18191077
- PMID:20828743
- PMID:20950601
- PMID:21538163
- PMID:21693179
- PMID:22047130
- PMID:29438107
- Patent:DE723278
- Patent:US2986573
- Patent:US3345365
- Reaxys:523907
- Wikipedia:Diazoxide
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
-
- has_role
Phenotype
Phenotype resulting from diazoxide
Phenotype where environments contain diazoxide
Phenotype modified by environments containing diazoxide
Human Disease Model