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Fig. 4
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Fig. 4 Fig. 4. TCC reprograms the transcriptome of the zebrafish anal fin joint by reducing the extracellular matrix. (A) Heatmap of the differentially expressed genes treated with TCC. (B) Multiple GSEA curves of subsets of genes encoding the extracellular matrix. (C) Distribution of genes within the GO term of collagen trimer according to GSEA analysis; (D) Heatmap revealing the changes in the expression of extracellular matrix- and inflammation-related genes after exposure to TCC.
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Reprinted from Journal of hazardous materials, 447, Zhang, Y., He, L., Yang, Y., Cao, J., Su, Z., Zhang, B., Guo, H., Wang, Z., Zhang, P., Xie, J., Li, J., Ye, J., Zha, Z., Yu, H., Hong, A., Chen, X., Triclocarban triggers osteoarthritis via DNMT1-mediated epigenetic modification and suppression of COL2A in cartilage tissues, 130747130747, Copyright (2023) with permission from Elsevier. Full text @ J. Hazard. Mater.