Gene

bglap

ID

ZDB-GENE-050113-4

Name

bone gamma-carboxyglutamate (gla) protein

Symbol

bglap Nomenclature History

Previous Names

bgp (1)
DrOC1 (1)
osteocalcin (1)
si:ch1073-504d15.2

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and hydroxyapatite binding activity. Involved in response to mechanical stimulus. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Is expressed in several structures, including osteoblast; renal tubule; scale; skeletal system; and trabecular layer. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

42 figures from 33 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bglap Human Ortholog

No data available

Associated With bglap Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
Family	IPR039176	Osteocalcin
Homologous_superfamily	IPR035972	Gamma-carboxyglutamic acid-rich (GLA) domain superfamily