ZFIN Image: Madakashira et al., 2021, Figure 6

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Figure 6

uhrf1 loss disrupts hepatocyte nucleoli and laminB2 organization. (A). Control and uhrf1^−/− hepatocyte nuclei scored at 80, 96, and 120 hpf for the number of nucleoli per hepatocyte. (B). Differential expression of nucleoli-associated genes in 120 hpf uhrf1^−/− livers, nc: not significantly changed (C). Control and uhrf1^−/− hepatocyte nuclei scored at 80, 96, and 120 hpf for the presence of normal lamina. (D,E). Confocal images comparing the immunostaining of LaminB2 in 120 hpf uhrf1^−/− and dnmt1^−/− livers with their respective WT controls. (F). Quantitative changes in LaminB2 staining in 120 hpf uhrf1^−/− and dnmt1^−/− hepatocyte nuclei. The numbers of LaminB2 positive nuclei are indicated below each bar. White arrows mark LaminB2 positive hepatocyte nuclei. All analyses were performed on 2 or 3 clutches, with minimum 3 livers analyzed per clutch. ** p < 0.005, *** p < 0.0005, **** p < 0.00005. Magnification: 63×, Scale bar: 7 μm.

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Acknowledgments

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