Gene

rpl3

ID

ZDB-GENE-030131-1291

Name

ribosomal protein L3

Symbol

rpl3 Nomenclature History

Previous Names

wu:fa99g02
wu:fb65e09
zgc:110350

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within exocrine pancreas development. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in eye; liver; and pancreas. Used to study Shwachman-Diamond syndrome. Orthologous to human RPL3 (ribosomal protein L3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110350 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rpl3 Human Ortholog

No data available

Associated With rpl3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Shwachman-Diamond syndrome	rpl3^hi2437Tg/+; jh1Tg; jh2Tg	standard conditions	Provost et al., 2012

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019926	Large ribosomal subunit protein uL3, conserved site
Family	IPR000597	Large ribosomal subunit protein uL3
Family	IPR045077	Large ribosomal subunit protein uL3, archaeal/eukaryotic-type
Homologous_superfamily	IPR009000	Translation protein, beta-barrel domain superfamily
Homologous_superfamily	IPR044892	Ribosomal protein L3, domain 3, archaeal-type superfamily

Domain Details Per Protein

Protein	Length	Large ribosomal subunit protein uL3	Large ribosomal subunit protein uL3, archaeal/eukaryotic-type	Large ribosomal subunit protein uL3, conserved site	Ribosomal protein L3, domain 3, archaeal-type superfamily	Translation protein, beta-barrel domain superfamily
UniProtKB:Q6Q418 InterPro	403
UniProtKB:A0A2R8Q924 InterPro PDB	403

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rpl3-201 (1) Ensembl	Ensembl	1,382 nt	Select Tool ZFIN BLAST
mRNA	rpl3-202 (1) Ensembl	Ensembl	738 nt	Select Tool ZFIN BLAST
mRNA	rpl3-204 (1) Ensembl	Ensembl	1,212 nt	Select Tool ZFIN BLAST
ncRNA	rpl3-002 (1) Ensembl	Ensembl	801 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations