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Fig. 4
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Fig. 4
AV canal marker gene expression analysis in id4 mutants at 52 hpf. Myocardial (tbx2b, bmp4, cspg2a) and endocardial (has2, spp1) AVC marker gene expression was analyzed in embryos from incrosses of id4 heterozygous animals. After in situ hybridization, embryos were separated according to expression patterns and subsequently genotyped. Amongst these markers, tbx2b and has2 expression were found to be unchanged, bmp4 and cspg2a were misexpressed and spp1 expression was reduced in id4 mutants. Scale bars, 100 µm.
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Reprinted from Developmental Biology, 412(1), Ahuja, S., Dogra, D., Stainier, D.Y., Reischauer, S., Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development, 71-82, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.