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Fig. 7 Midline gene expression is expanded in aus mutant embryos. Lateral views of gene expression in wild-type (A,C,E,G) and aus mutant (B,D,F,H) dissected prim-12 stage brains with rostral to the left. The asterisks indicate the positions of the anterior and postoptic commissures. (A,B) noi/pax2.1. Expression around the optic recess is expanded and there is ectopic expression within the telencephalon of the aus mutant embryo. (C,D) ace/fgf8. Expression is upregulated throughout much of the rostral/dorsal forebrain of the aus mutant embryo. (E,F) net1a. Expression is upregulated in the aus mutant embryo, particularly around the optic recess. (G,H) shh. Expression domains are slightly disrupted in the aus mutant but generally similar to the wild-type embryo. Abbreviations: AC, anterior commissure; d, diencephalon; mb, midbrain; POC, postoptic commissure; t, telencephalon; wt, wild type. Scale bar: 30 μm.