Gene

ntn1a

ID

ZDB-GENE-990415-169

Name

netrin 1a

Symbol

ntn1a Nomenclature History

Previous Names

net1a (1)
ntn2
net2
zgc:136732

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Involved in several processes, including circulatory system development; closure of optic fissure; and generation of neurons. Predicted to localize to basement membrane. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Is expressed in several structures, including brain; head; optic cup; optic vesicle; and somite. Orthologous to human NTN1 (netrin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

32 figures from 23 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 18 figures from 11 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ntn1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Mirror movements 4	618264

Associated With ntn1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001134	Netrin domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR008211	Laminin, N-terminal
Domain	IPR018933	Netrin module, non-TIMP type
Family	IPR050440	Laminin/Netrin Extracellular Matrix
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold