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Fig. 4
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Fig. 4
Rescue of the MHB program in gbx-embryos with otx knock-down. RNA in situ hybridization with genes shown on left; genotypes indicated at the top. Dorsal views of 22 hpf embryos with anterior to the left. (A–T) fgf8a, il17rd/sef, gbx2, pax2a and eng1b are all expressed at or around the MHB, are absent or strongly reduced in gbx- but are expanded in both otxMO and gbx-;otxMO embryos. (U–X) wnt1 is normally expressed in a narrow domain anterior to the MHB (U). This expression is reduced in gbx- (V) but rescued anterior to the extended isthmic region in otxMO (W) and gbx-;otxMO (X).
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Reprinted from Developmental Biology, 386(1), Su, C.Y., Kemp, H.A., and Moens, C.B., Cerebellar development in the absence of Gbx function in zebrafish, 181-90, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.