ZFIN Image: Abrams et al., 2012, Fig. 2

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Fig. 2

Nuclear Membrane Fusion Is Disrupted in bmb Mutants(A) Frames from time-lapse experiments at the telophase-interphase transition demonstrate that chromatin bodies normally coalesce in WT (top) but fail to do so in bmb (bottom). Note: six frames were selected (from Movies S1 and S2) to best align the sequence of events between WT and bmb at the telophase-interphase transition.(B) Electron microscopy of WT versus bmb at the telophase-interphase transition. Embryos at the 128-cell stage were fixed at 90 s intervals for transmission electron microscopy (TEM). Black bar, 2 microns. The inset in WT (0 min) is enlarged 2× to show the double-membrane nuclear envelope. For each time point, n = 2 embryos. Multiple cells from each embryo were examined in both WT and bmb.

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Acknowledgments

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Reprinted from Cell, 150(3), Abrams, E.W., Zhang, H., Marlow, F.L., Kapp, L., Lu, S., and Mullins, M.C., Dynamic Assembly of Brambleberry Mediates Nuclear Envelope Fusion during Early Development, 521-532, Copyright (2012) with permission from Elsevier. Full text @ Cell