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Fig. 1
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Fig. 1
mmy mutants have severe defects in primitive hematopoiesis. A: Whole-mount in situ hybridization of myeloid markers (l-pln, lysc, and mpo) at 24 hpf. B: Expression of erythroid markers αe1 and αe2 globins, band3 and gata1 at 21 somite. C: Stem cell markers cbfb and scl are also down-regulated in mmy mutants. D: Acridine orange staining showing extensive apoptosis in mmy mutants through the entire embryos. For all probes tested, we typically used 30–40 embryos per hybridization. As such, 25% (8–10 embryos) will be mmy.
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