Gene
cbfb
- ID
- ZDB-GENE-980526-440
- Name
- core-binding factor subunit beta
- Symbol
- cbfb Nomenclature History
- Previous Names
-
- unp1266
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Exhibits protein heterodimerization activity. Contributes to DNA binding activity and transcription coregulator activity. Involved in several processes, including heart contraction; lymphoid lineage cell migration into thymus; and myofibril assembly. Localizes to Z disc and core-binding activity factor complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Is expressed in several structures, including digestive system; ganglia; hematopoietic system; immune system; and pericardial region. Orthologous to human CBFB (core-binding factor subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cleidocranial dysplasia 2 | 620099 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Core-binding factor, beta subunit | Core-binding factor, beta subunit superfamily |
|---|---|---|---|
|
UniProtKB:A0A140LGT1
|
201 | ||
|
UniProtKB:A0A0B4P506
|
174 | ||
|
UniProtKB:Q98U16
|
187 | ||
|
UniProtKB:A0A0B4P4A4
|
188 | ||
|
UniProtKB:A0A8M9PQ04
|
180 | ||
|
UniProtKB:A0A0B4PIS7
|
187 | ||
|
UniProtKB:A0A8M2B5H7
|
200 |
Interactions and Pathways
No data available
Plasmids
No data available