ZFIN Image: Ravanelli et al., 2011, Fig. 4

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Figure Caption

Fig. 4 cobl morphants display abnormal left–right molecular asymmetry.

RNA in situ hybridization of spaw (A-D) in control and morphant embryos from 16 to 20 somites. (E) Bar graph showing the percentage of treated embryos displaying spaw expression on the left, right (R), bilaterally (Bi) or absent expression (Abs). RNA in situ hybridization of pitx2 (F–I) in control and morphant embryos from 19 to 23 somites. (J) Bar graph showing the percentage of treated embryos displaying the pitx2 expression pattern seen in F–I. Normally, spaw and pitx2 expression is induced only in the left lateral plate mesoderm by signals originating from Kupffer′s vesicle. Morphants express these genes on either the left or right sides, both sides, or not at all. Arrows indicate expression domain of spaw and pitx2.

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Acknowledgments

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Reprinted from Developmental Biology, 350(1), Ravanelli, A.M., and Klingensmith, J., The Actin Nucleator Cordon-bleu is Required for Development of Motile Cilia in Zebrafish, 101-111, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.